Provides nutritional support for horses undergoing Cushing’s syndrome

Active Ingredient: Cortidopatrophin™


Why is Revertol the top nutritional supplement for horses with Cushing’s syndrome?
Equine Cushing’s syndrome is a disorder of the adrenal cortex caused by a pituitary tumor that involves diabetic issues such as glucose intolerance and insulin resistance. Conventional drugs are used as treatments but are often ineffective because they tend to function via only one mechanism. Many veterinarians and equine practitioners fail to understand that by treating Cushing's symptoms alone they do nothing to treat the cause of the malady.

Now Rossana Figuerola, Ph. D., offers Revertol, a unique nutritional supplement based on her discovery that the successful management of equine Cushing’s mandates that all the known degenerative pathways be corrected by addressing the root of the problem. Significantly, Revertol addresses attendant diabetic issues without feeding glucosamine, a form of glucose that horses with Cushing’s should not take.

Developed by Figuerola Laboratories, Revertol is a state-of-the-art dietary supplement that enhances your horse’s ability to naturally target Cushing’s syndrome and its adverse effects. Revertol’s active compound, Cortidopatrophin, is an amino-phyto-mineral-peptide complex that:

• Helps correct hormonal malfunctions and enhance cortisol regulation by supporting the normal functioning of the pituitary gland
• Supports the body's ability to inhibit the enzymes that promote inflammation, which is believed to play a significant role in out-of-control cell growth
• Supports apoptosis, a process where potentially dangerous cells are instructed to "self-destruct"
• Offers a unique component of the blood-sugar-regulating molecule GTF (glucose tolerance factor), which works with insulin to facilitate the uptake of glucose
• Helps boost the immune system to fight secondary infections

What is the cause of Cushing’s in horses?
Equine Cushing's is usually caused by the degeneration of hypothalamic dopaminergic neurons and an inappropriate secretion of ACTH (adrenocorticotropic hormone) caused by a benign tumor in the pituitary gland.

What are the symptoms of equine Cushing’s?
The hormonal imbalance created by Cushing’s causes adverse reactions in a horse. The most dangerous effects are:

• A high propensity to laminitis
  • Laminitis is the most severe and life threatening complication of equine Cushing’s, and is the most common reason for euthanasia. Treatment with Pergolide® (see “Treatment options,” below) decreases the frequency and severity of episodes of laminitis by reducing the secretion of hormones that initiate laminitis. Unfortunately, the control of these secretions is incomplete, and mild episodes may come and go unnoticed.
• A weakened immune system, making a horse prone to many diseases
• Increased levels of insulin
• Insulin resistance
• Other effects include:
• A long, curly coat, with abnormal shedding periods (not shedding during the spring)
• Pot belly
• Increased water intake and urination
• Lethargy
• Muscle loss
• Rain rot and excessive sweating

The internal effects of equine Cushing’s include:

• Abnormal production of cortisol in the blood
• Abnormal fatty deposits
• Low thyroid levels
• Poor vision
• Inflammation

How is equine Cushing’s diagnosed?
In humans or dogs undergoing Cushing’s, the major hormone produced by the abnormal pituitary gland is ACTH, which stimulates the adrenal glands to overproduce cortisol. In horses, however, levels of cortisol are usually normal or even low. Blood and urine tests may be essential to diagnose Cushing’s disease. Recurrent testing may be necessary, as preliminary tests do not always produce definite results.

The two most practical tests for equine Cushing’s are the dexamethasone suppression test and measurement of plasma ACTH concentration.
Dexamethasone Suppression Test
This test involves taking a blood sample in the late afternoon, followed by a low-dose dexamethasone injection. A second blood sample is collected at noon the following day. Both samples are measured for plasma cortisol. In normal horses, administration of dexamethasone stimulates a negative-feedback response that suppresses secretion of cortisol from the adrenal glands, yielding a much lower concentration in the second blood sample. In horses suffering from Cushing’s, however, a lower degree of suppression, if any, is observed.

Although the dexamethasone suppression test is widely considered the most accurate test currently available for diagnosing equine Cushing’s, it has two significant drawbacks: (1) It requires two veterinarian visits, which can be costly, and (2) The administration of dexamethasone may increase the risk of laminitis in a horse that is already predisposed to laminitis.
Measurement of Plasma ACTH
Because of the risks associated with the dexamethasone test, some veterinarians prefer an alternative test: measurement of plasma ACTH. This involves collection and analysis of a single blood sample, which can indicate that the pituitary gland is secreting excessive amounts of ACTH (as compared to normal horses). While useful, this test is generally considered to be somewhat less accurate than the dexamethasone suppression test, and blood samples must be handled very carefully to avoid degradation of ACTH and falsely low measured values. (Stress and pain due to other conditions may also result in falsely elevated values.)

Supplemental tests that may also be useful in horses suspected of Cushing’s include measurements of blood glucose and insulin. Many affected horses are insulin resistant and some are significantly hyperglycemic, and early recognition and tracking of these problems can lead to helpful nutritional management of the disease and provide additional criteria by which to evaluate the horse’s response to treatment.

What are the treatment options for equine Cushing’s?
In some cases, Cushing’s is so evident to a veterinarian that treatment is prescribed in advance of testing. After testing and a positive diagnosis, targeted treatment can begin. Cushing’s syndrome has no cure. The three most commonly used drugs for managing equine Cushing’s are:

• Pergolide® (Permax). This drug was originally used to treat human Parkinson's disease. Pergolide® mesylate is usually administered orally, in tablet form (Crushing the tablets with a little honey is an effective way to dose your horse)
• Cyproheptadine® (Periactin). This seratonin blocker is available in tablet form, which is easily absorbed into the horse's system. Horses have to be maintained on cyproheptadine®. Cyproheptadine® is effective in about 75 percent of cases
• Bromocriptin® (Parlodel) is a less trendy drug used to treat equine Cushing’s, although still used by some veterinarians. Problems in absorption are often documented, and the drug purportedly produces a number of side effects

It is important to understand that, while these drugs treat the symptoms, they do not treat the pituitary tumor itself, which will continue to grow until it compromises the horse's quality of life. There are presently no techniques for removing or curbing the growth of equine pituitary adenomas.

When making a decision about whether to medicate a horse with Cushing’s, you should initially consider the cost and the condition of the horse in question. Horses with moderately gentle symptoms usually respond best to medication, which may extend their useful lives for a number of years. However, a horse that is already suffering from chronic founder or laminitis and periodic infections as a result of immune system failure will likely derive very little benefit.

Other help for horses with Cushing’s
Whether or not your Cushing’s horse is receiving medication, you can help him feel as comfortable as possible by following these guidelines:

• Nutrition is critical for general and immune-system health. Maintain your horse with the best diet possible. Consider supplementing with Figuerola Laboratories’ EquineSaver, GlycoElastin, and/or LaminaSaver
• Eliminate excessive carbohydrate consumption (oats, sweet feed, lush grass, etc.)
• Provide your horse with regular professional shoeing and trimming
• Give your horse professional dental care twice a year
• Keep immunizations to a minimum but make sure all necessary shots are given
• De-worm regularly, as recommended by your veterinarian (usually every 45 days)
• Groom your horse periodically to minimize skin diseases
• Provide your horse with a comfortable and familiar shelter, with water and feed conveniently located
• Decrease excessive exercise for your horse in warm weather, and use blankets in cold weather
• Reduce stress by initiating a strict routine for your horse
• Reduce stress by avoiding turning your horse out with aggressive horses

Powder Supplement.


Administration
Administer 1 scoop twice daily.


Ingredients
Cortidopatrophin Proprietary Formula: SUPPRESOL (Squalus acanthias extract, Tracheal acanthias extract, D-Glucaric acid, Indole-3-Carbinol and Fenretinide), L-Carnosine, Phosphatidylserine, Angi casti fructus (Vitex agnus-castus), Alpha-calacorene, Bis-glycinato oxovanadium (BGOV), Alpha-copaene, Brevifolin, Dehydroepiandrosterone (DHEA), Superoxide Dismutase (SOD), Punica granatum, LIGNANFORTE (Lignan concentrate), Carboxylic acids, Withania somnifera, Commiphora mukul, Corilagin, Cymene, Ellagic acid, Ellagitannins, Gallocatechins, Glycyrrhiza glabra extract, Geraniin, Hypophyllanthin, alpha-Pinene, alpha-Thujone, beta-Caryophyllene, beta-Elemene, beta-Pinene, Betaine, Bincatriol, Borneol, Calamenene, Quercetol, Quercetin, Rutin, Camphene, catechins, Cedrucine, Crolechinic acid, Cuparophenol, Gymnemic acid, D-Limonene, Daucosterol, Dihydrobenzofuran, Pterocarpus marsupium extract, PURPUREX (Purple Corn Extract), Eugenol, Dimethyl cedrusine, Dipentene, Euparophenol, Gallocatechol, gamma-Terpinene, gamma-Terpineol, Hardwickiic acid, Isoboldine, Korberin A, Korberin B, Lignin, Linalool, Magnoflorine, Methylthymol, Myrcene, Norisoboldine, P-Cymene, Tannin, Taspine, Proanthocyanidins, Vanillin, Saponin, Triacontanol, Terpinen-4-ol, Evodiamine extract, INHIBITOL (50% Salicin Complex (Purpura salix, Fillipendula ulmaria and Gaultheria procumbens), 65% Boswellic Acid Extract (Rhizome), 45% Poliphenols (Camelia sinensis), 50% Resveratrol (Polygonum cuspidatum), 6% Berberine (Barberry and Chinese goldthread), Alkaloid Complex Extract (Uncaria Tomentosa), Origanum vulgare extract, 2% Ursalic acid (Ocimun basilicum), 95% Procyanidins (Vitis vinifera), 23% Phenolics (Rosmarinus ocinalis), Gamma-Tocopherol (Elais gueneensis), Gamma-Tocotrienol (Elaeis gueneensis) and Superoxide Dismutase), Salisorosides, Glycyrrhizic acid, L-Ornithine-Alpha-Ketoglutarate, L-Arginine-Alpha-Ketoglutarate, L-Theanine, Alpha-lipoic acid, Acetyl-L-Carnitine, Phyllanthus niruri extract, Lutein, Zeaxanthin, L-DOPA, Corosolic Acid, L-Tyrosine, Lepidium meyenii, IODINE FORTE (Kelp extract, Fucoidan, Bladderwrack, Seaweed extract and Red marine algae extract), Spirulina, Vaccinium macrocarpa extract, Trigonella foenumgraecum extract, OMEGA-FORTIS (Omega-3 fatty acid, Omega-6 fatty acid and Omega-9 fatty acid), Magnesium oxide 4g, Magnesium amino-acid chelate 2g, Boron 20mg, Biotin 3mg, Riboflavin 0.4g, Niacinamide 0.5g, Adenine 50mg, Pantothenic Acid 6mg, Pyridoxine 1g, Folic Acid 8mg, Methylcobalamin 50mg, Chromium Polynicotinate 2mg, ABSORBA-MAX and GLANDFORTIS (Purified Calf Thymus Extract, Thyroid Freeze-Dried Tissue, Pituitary Freeze-Dried Tissue and Freeze-dried Raw Spleen Tissue (bovine)).


*Pergolide®, Cyproheptadine®, and Bromocriptin® are registered trademarks of their respective owners.

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.