Provides nutritional support for horses needing maximum flexibility and mobility, and who have undergone severe joint distress

Active Ingredient: Regenerex-MP™


What is JointSaver?
JointSaver is a superior, one-of-a-kind therapeutic nutraceutical that provides extra-strength, full-spectrum joint tissue support for your horse. JointSaver’s proprietary active ingredient, 100% Regenerex-MP, is an ultra-low molecular weight (LMW) synergistic formulation that goes to work immediately to help repair and regenerate articular (joint) cartilage and its connective tissues.

JointSaver is the only proven joint-support product that contains Regenerex-MP, to which Figuerola Laboratories holds exclusive rights. Every batch of JointSaver is tested for uniformity and consistency, and is subject to strict quality control measures. Do not accept substitutes or lookalike imitations that cannot duplicate JointSaver’s excellent results. Unwary horse owners can waste valuable time and money—and, most critically, risk the health of their horses—by using less effective supplements that often do not contain the levels of glucosamine, chondroitin, or MSM needed for optimal joint function.

How does JointSaver help support the health of your horse’s joints?
JointSaver and its active ingredient, Regenerex-MP, naturally help protect your horse against joint tissue damage and maintain your horse’s joint-tissue health.

JointSaver helps:

• Increase joint mobility and flexibility by restoring the "shock-absorbing" and "cushioning" properties of your horse’s joints
• Fight damaging enzymes that contribute to cartilage breakdown
• Promote new cartilage cell synthesis by reducing oxidative damage to the joints
• Normalize injured joint tissue, while lubricating and maintaining healthy joint and connective tissue function
• Fight arthritic joint-lubricant degradation by triggering haluronic acid, the “glue” that holds cartilage cells together
• Decrease joint inflammation
• Encourage cartilage rebuilding and renewal

What is the extraordinary function of joint cartilage?
One of the extraordinary functions of articular cartilage is its ability to replenish its major compounds in response to the mechanical forces placed on it.

Cartilage (the "cushion" at the end of the bones where they come together to form a joint) is composed of specialized cells called chondrocytes surrounded by a gelatinous matrix of collagen and proteoglycans. This matrix of immense molecules gives cartilage its property of elastic strength and resilience.

• Collagen, the tough protein that physically connects the tissue, provides the elastic strength of cartilage.
• Proteoglycans consist mainly of hyaluronic acid, “the glue” that holds cells and glycosaminoglycans (GAGs) together and is responsible for the normal high flexibility of synovial fluid (the fluid secreted by the lining of the joint to nourish and lubricate the joint). The water-structuring properties of proteoglycans provide the compressive resilience of cartilage.

The constant and ongoing process of cartilage manufacturing and remodeling tremendous amounts of collagen and proteoglycans often generates extremely large demands for these building blocks. If their raw materials (nutrients) are not available in the amounts required, the synthesizing process is impaired and the cartilage loses its ability to replenish itself.

How do training and exercise affect the joints, cartilage, synovial fluid, and connective tissues?
Submerged in synovial fluid, articular cartilage performs its main function by providing a smooth friction between bone edges to prevent abrasive wear and damage that may eventually result in bone fusion.

The titanic forces applied to the joint cartilage during training and competition can cause rub-off and splitting of the joint cartilage, resulting in compromised physical performance of the skeletal joints, cartilage, synovial fluid, and connective tissues in the stifle, knee, hock, and fetlock, stifle. Any of these problems can severely affect athletic equine performance regardless of how well trained, muscular, or biomechanically perfect your horse is.

If your horse develops equine osteoarthritis—sometimes caused by stresses like training and exercise—concentrations of hyalorunic acid are reduced in the cartilage and in synovial fluid, and its properties in osteoarthritic joint fluid are abnormal, comprising smaller, less shock-absorbing molecules.

What is equine osteoarthritis?
Equine osteoarthritis is the painful and destructive inflammation and enzyme production that causes a horse’s body to literally consume its own joint-added cartilage and joint lubricants. It is caused by stress, competition- and performance-related activities, trauma, or age, and is characterized by joint pain, joint stiffness, and muscle pain.

Equine osteoarthritis primarily affects weight-bearing joints in horses, including:

• The pastern joint and coffin joint (where it is referred to as ring bone when more severe)
• The hock (ankle—where it is commonly referred to as bone spavins)
• The fetlock
• The spine (neck and back—less common)
• The stifle (less common)

Osteoarthritis does not usually affect other equine joints, except where previous injury has occurred or areas where there has been repetitive or abnormal stress.

How is equine osteoarthritis currently treated?
Treatment is essentially limited to the use of a few anti-inflammatories, mainly corticosteroids and phenylbutazone (bute). The anti-inflammatories help limit current damage but do nothing to protect or restore ravaged areas, and some of them, especially phenylbutazone, when used at the sustained dosage needed for continued athletic performance, can cause harsh side effects, including gastrointestinal erosion, ulceration, and formation of kidney lesions. Recent studies have shown that corticosteroids and phenylbutazone may also cause further damage to joint cartilage.

Why is JointSaver superior to any other equine joint-support product?
JointSaver is the one and only therapeutic treatment with Regenerex-MP, a powerful, 100% pure formula including the important nutrients glucosamine and chondroitin, which are essential for the synthesis of synovial fluid and the complete cartilage matrix. JointSaver also supplies the highest amounts of glycosaminoglycans (GAGs) or mucopolysaccharides (MPs), which fight arthritic joint-lubricant degradation by triggering production of hyaluronic acid, the “glue” that holds cartilage cells together.
JointSaver helps:

• Regenerate cartilage and repair joint tissue
• Provide support for a variety of connective tissue diseases, and helps maintain healthy bones, joints, ligaments, cartilage, tendons, synovial fluid, and connective tissues
• Prevent osteoporosis, arthritis, bursitis, and navicular injuries triggered by stress, sport-related activities, trauma, or age
• Produce major reductions in joint pain, tenderness, and swelling

How does Regenerex-MP work to help increase your horse’s joint mobility and flexibility?
Figuerola Laboratories’ powerful proprietary formula, Regenerex-MP, comprises 100.5+% pure glucosamine HCL, 99.9+% pure low molecular weight chondroitin sulfate, 24% pure low molecular weight hyaluronic acid, 99.9% pure GlycoElastin, 99.9+% pure MSM (methylsulfonylmethane), 100% pure SAMe (S-Adenosylmethionine), 100% pure CMGP (cartilage matrix glycoprotein), and eight antioxidant vitamins (A, C, E) and minerals (copper, manganese, selenium, silicon, zinc picolinate).

Through these ingredients, Regenerex-MP helps promote the biosynthesis of rebuilding and renewing joint cartilage and its connective tissues.

• Glucosamine is the main structural component of healthy joints and connective tissues, and helps increase joint strength, mobility, and flexibility, while enhancing the body's natural ability to control inflammation. Its primary functions are to stimulate the secretion of glycosaminoglycans (GAGs) in the articular cartilage, enabling joint cartilage regeneration and connective tissue repair, and to stimulate cartilage cells to produce proteoglycans, the proteins that bind water in cartilage. Researchers have also found that administration of glucosamine suppresses nitric oxide production, which may be a key factor in helping to prevent inflammation.
• Chondroitin sulfate is a major structural component found in cartilage. Its primary function is to inhibit degradative enzymes that contribute to cartilage breakdown. Regenerex-MP’s low molecular weight chondroitin sulfate protects and stabilizes collagen while enhancing elasticity and cushioning of joints.
• Hyaluronic acid (hyaluronan) is normally part of cartilage and synovial fluid. Because of its low molecular weight (LMW), Regenerex-MP’s hyaluronic acid travels through the bloodstream immediately and provides a higher absorption rate. It also offers a higher concentration of hyaluronic acid (24%) than do other supplements.
  • In cartilage, hyalorunic acid binds to other molecules, helping the cartilage to withstand the force of weight bearing and movement of the joint.
  • In the synovial fluid, hyalorunic acid lubricates the movement of the cartilage against the lining of the joint (synovium) and also may have some "shock absorber" properties.
  • Clinical research indicates that supplemental LMW hyaluronic acid may decrease swelling and inflammation; may reduce pain by soothing irritated nerve endings in the lining of the joint; and may help to stimulate the production of normal hyalorunic acid by the cells in the joint lining and improve stiffness present in horses facing degenerative arthritis (osteoarthritis).
  • In addition, LMW hyaluronic is often helpful in maintaining healthy skin, acting as an anti-aging agent, and improving immune function.
• GlycoElastin is a unique proprietary formula developed exclusively by Figuerola Laboratories to help support healthy joints by promoting new cartilage synthesis, promoting healing, and supplying rejuvenating agents.
  • GlycoElastin is literally the "super glue" that holds cartilage cells together, containing essential nutrients needed to support cartilage synthesis: collagen complex, GAGs complex (glucosamine sulfate, LMW chondroitin sulfate, LMW hyaluronic acid), and 19 essential amino acids (alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine).
  • GlycoElastin helps promote maximum oxygen transport to ailing joints, a key factor that allows rapid healing of articular (joint) cartilage, its connective tissues, and surrounding tissues.
  • GlycoElastin helps inhibit the inflammatory cascade.
• Methylsulfonylmethaene (MSM) is an excellent source of bioavailable sulfur. It provides nutrients that induce the production of collagen, and is responsible for the conformation of body protein. MSM provides analgesic properties and anti-inflammatory effects. It offers elasticity, flexibility, and permeability to soft tissue—the ability to stretch.
• S-Adenosylmethionine (SAMe) combines the essential amino acid methionine with adenosyl-triphosphate (ATP), an important physiological agent that occurs naturally in the body. SAMe is required in the manufacture of all sulfur-containing cartilage components, and a deficiency of SAMe in joint tissue—just like a deficiency of glucosamine—leads to the loss of the "gel-like" nature and "shock-absorbing" qualities of cartilage. (Recent studies suggest that SAMe may restore flexibility and strength to joints and connective tissues, while enhancing the body's ability to control inflammation.)
• Cartilage matrix glycoprotein (CMGP) is a newly discovered antioxidant proteoglycan that helps protect the cartilage surface from oxidative damage and enzyme digestion.
  • CMGP helps promote new cartilage cell synthesis, and proteoglycan synthesis, while enhancing the production of synovial fluid for the joint itself.
  • CMGP carries superoxide dismutase (SOD) and copper to the chondrocytes. SOD is a powerful free radical scavenger that helps transport maximum oxygen to joints and connective tissues (a key factor enabling rapid recover of ailing joints), and copper is a chondro-protective mineral that ensures proper levels of SOD in the cartilage surface.
  • By helping to restore proper chondrocyte and cytokines programming, CMGP also acts as a powerful anti-inflammatory and pain modulator.
• Eight vitamins and minerals fortify Regenerex-MP to promote new collagen and protein synthesis and enhance the formation of cartilage, ligaments, tendons, synovial fluids, and connective tissues.
  • Regenerex-MP includes vitamin A (beta carotene), vitamin C (ascorbic acid), and vitamin E (alpha tocopherol) and copper, manganese, selenium, silicon, and zinc picolinate.
  • These vitamins and minerals act as powerful antioxidants that help protect against free radical damage and as essential co-factors for the biosynthesis of GAGs.

How long does it take to see results from JointSaver?
Since JointSaver provides nutrients that affect the structure and function of the joint, changes may occur gradually. You should notice changes in two to four weeks in most horses. Some horses may take four to six weeks to show noticeable changes.

Are there any side effects with JointSaver?
None. JointSaver’s non-toxic formula is very safe to use, even at overdose levels.

Does JointSaver have any anti-inflammatory properties?
Yes, JointSaver does have some secondary anti-inflammatory effects. However, that is not its key function. It helps to alleviate pain by normalizing damaged joint tissue. That’s why it may take JointSaver a few weeks before there is a noticeable improvement. Arthritis medications can relieve pain immediately, but they are only temporary and can be accompanied by further damage to the joint.

Can JointSaver be supplemented with a natural, nutritional anti-inflammatory?
Yes. Figuerola Laboratories offers InflammaSaver, a natural alternative to other anti-inflammatories (such as bute) that reduces inflammation without jeopardizing your horse’s health. Information on InflammaSaver is available in this product guide.


Powder Supplement.


Administration
Administer 1 scoop twice daily for 6 weeks. Thereafter administer ½ scoop twice daily.


Ingredients

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.