Provides nutritional support for horses with moderate to severe pain and inflammation

Active Ingredient: Inhibitol

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Unfortunately, too few equine practitioners understand that inflammation, pain, and tissue damage are caused by multiple pathological factors, and that chronic inflammation may ultimately lead to even more serous health problems for your horse. The main reason for the high malfunction rate of over-the-counter and prescription analgesic and anti-inflammatory drugs is that they work by targeting only one of the body’s systems. Now Rossana Figuerola, Ph. D., has discovered that the successful management of inflammation and pain and the cascade of dysfunctional symptoms they cause requires that all the known degenerative pathways be restored to proper functioning.

The most dangerous inflammatory-inducing factors are cyclooxygenase-2 (COX-2), 5-lipooxygenase (5-LOX), tumor necrosis factor alpha (TNF-A), and interleukin-1 beta (IL-1b). Figuerola Laboratories has developed InflammaSaver and its active ingredient, Inhibitol to attack the several causes of pain and inflammation with an innovative, multifaceted, natural approach that targets present pain and reduces the chronic inflammation that may cause future disease and disability.

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What is chronic pain?

The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Chronic pain is discomfort that lasts longer than six months. Pain intensity may be influenced by the nature of the bodily injury or condition, as well as by environmental and psychological factors.

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What is inflammation and what causes it?

Inflammation is the body’s natural response to injury. It is characterized by redness, swelling, increased temperature, and pain. When your horse’s soft tissues become inflamed, he may experience any or all of these symptoms. Any organ or tissue of the body can become inflamed, either internally or externally. Inflammation can originate from bacterial or viral infection, physical trauma, or a bodily disorder such as arthritis. External inflammation is usually the result of injury.

-------------

How is inflammation usually treated?

Inflammation is currently treated by painkillers and anti-inflammatory medications. While it is true that restoration of normal movement is the key to restoring healthy, pain-free bodily functions, these medications should only be used for the short term, to encourage movement. Although your horse may respond quickly to anti-inflammatories, these drugs often mask pain, while the underlying cause of inflammation remains untreated. In most cases, anti-inflammatories act simply as painkillers, and should only be used in conjunction with regular and appropriate exercise.

-------------

Are commonly used commercial drugs safe and effective?

Inflammation is usually treated with corticosteroids, phenylbutazone (bute), and non-steroidal anti-inflammatory drugs (NSAIDs). These drugs work by blocking the production of prostaglandins (hormone-like chemicals in the body) that cause pain, inflammation, and cramping. However, prostaglandins also have many essential physiological functions, including regulation of blood pressure, kidney function, and gastric acidity.

Scientists have found that continuous high doses of drugs that inhibit prostaglandin synthesis increase the risk of cumulative toxicity. Some anti-inflammatory drugs, in particular phenylbutazone, can produce serious side effects, such as stroke, heart attack, gastric irritation, stomach ulcerations, bleeding, altered metabolism, and a weakened immune system. Bute has also been shown to cause further deterioration to connective tissues and has been implicated in loss of appetite, changes in blood chemistry, bone marrow depression, kidney damage, etc.

-------------

Why are many prescribed anti-inflammatory pain drugs often ineffective?

Inflammation and pain are caused by a multi-faceted process, yet most drugs prescribed to lessen inflammation and pain function by using only one of the body’s numerous mechanisms. For instance, COX-2 inhibitor drugs suppress the enzyme cyclooxygenase-2 (COX-2), but do not block the other inflammatory enzyme 5-lipooxygenase (5-LOX).

While a COX-2 inhibitor may provide temporary relief, underlying cartilage damage can continue as inflammatory agents generated by 5-LOX continue to destroy joint cartilage. In addition, destructive cytokines such as tumor necrosis factor alpha (TNF-a) and interleukin-1 beta (IL-1b) cause inflammation and are directly involved in cartilage and bone destruction and organ deterioration. Even if veterinarians prescribe drugs to inhibit COX-2, 5-LOX, TNF-a and IL-1b, other destructive enzymes such as collagenase and phospholipase can continue to trigger the inflammatory process.

-------------

Why are some anti-inflammatory drugs ineffective and sometimes dangerous?

Again, most of these drugs use only one of the body’s systems to control inflammation by inhibiting COX-2 or suppressing TNF-a or lowering IL-1b. In addition, cartilage degeneration, which causes arthritis pain, originates from a variety of different factors, so FDA-approved drugs usually provide only partial pain relief. Finally, some of these drugs are also associated with mild to lethal side effects, because they inhibit good enzymes that are essential for the body’s healthy functioning: COX-2 inhibitors like Meloxicam, Carprofen, and Eetodolac have been implicated in serious side effects associated with irreversible COX-1 inhibition.

-------------

Can inflammation cause long-term degenerative diseases in a horse?

Many equine degenerative diseases originate with inflammation. Normally, inflammation is a positive process. When your horse experiences a cut, for example, that turns red and swells, his immune system is responding naturally, sending white blood cells and other hormone-like substances to help start the healing process. But not every kind of inflammation is so easy to see, and it's the invisible inflammation that can take place throughout the body that is attracting the increasing scrutiny of scientists and equine practitioners.

Systemic inflammation appears to be an underlying cause of many age-related diseases. As horses grow older, systemic inflammation can inflict devastating degenerative effects throughout the body. The dangers of systemic inflammation have often been overlooked by veterinarians, yet persuasive scientific evidence suggests that correcting a chronic inflammatory disorder can prevent and even reverse infirmities associated with aging. Following specific prevention protocols can significantly reduce inflammatory cycles that damage the body and prevent its healthy, long-term maintenance.

-------------

What diseases and disabilities may be related to chronic inflammation?

Equine practitioners have begun to believe that chronic inflammation may play a part in triggering a number of serious equine diseases and conditions, including:

Allergies (inflammatory cytokines induce autoimmune reactions)

Anemia (inflammatory cytokines attack erythropoietin production)

Aortic valve stenosis

Arthritis (inflammatory cytokines destroy joint cartilage and synovial fluid)

Cancer (chronic inflammation causes many cancers)

Congestive heart failure (chronic inflammation contributes to heart muscle wasting)

Dermatitis (inflammatory cytokines induce dermatitis)

Diabetes (inflammatory cytokines lead to damage of the eyes, kidneys, peripheral circulation, immune system, brain and neurological systems, and cardiovascular system)

Epiphysitis (damage to the growth plates of the bones, occurring most frequently in younger animals)

Fibrosis (inflammatory cytokines attack traumatized tissue)

Heart attack (chronic inflammation contributes to coronary atherosclerosis)

Hypercholesterolemia (excess cholesterol—chronic inflammation leads to oxidation of cholesterol and deposits in blood vessels)

Kidney failure (inflammatory cytokines restrict circulation and damage nephrons)

Muscle tension/spasms

Obesity (chronic inflammation leads to the development of excess fat which serves as endocrine organ to release inflammatory cytokines)

Osteochondrosis (caused by a defect in the cartilage overlying the head of one of the long bones)

Pancreatitis (inflammatory cytokines induce pancreatic cell injury)

Spondylosis (formation of bone spurs in the vertebrae, usually affecting older animals)

Stroke (chronic inflammation promotes the occurrence of thromboembolic events)

Surgical complications (inflammatory cytokines prevent healing)

Tendonitis

-------------

What causes age-related inflammation?

As your horse grows older, there is an increased production of numerous pro-inflammatory chemicals such as cytokines, prostaglandin (G2), C-reactive protein, and thromboxane (A2). These body chemicals lead to the progression of many degenerative diseases, including arthritis, cardiovascular diseases, obesity, and diabetes, among others. Age-related rheumatoid arthritis is a classic autoimmune disorder in which excess levels of cytokines such as tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), interleukin 1-alpha (IL-1a), INF-gamma, and/or interleukin-8 (IL-8) are known to cause or contribute to inflammation.

-------------

What are cytokines and why are they important?

Cytokines are proteins that serve as signaling chemicals and are secreted by various types of immune cells. The main role of cytokines is to control the direction, amplitude, and duration of the inflammatory response. There are two main groups of cytokines: pro-inflammatory and anti-inflammatory. Pro-inflammatory cytokines are primarily produced by activated immune cells and are involved in the amplification of inflammatory reactions. When a cytokine blood profile is conducted on horses in a weakened condition, an excess level of one or more of the inflammatory cytokines, e.g., TNF-a, IL-6, IL-1b, or IL-8, is usually found.

-------------

How does InflammaSaver help preserve proper cytokine production?

The active ingredient in InflammaSaver is 100% pure Inhibitol, a proprietary low-molecular-weight formula scientifically designed to help diminish pain and Inflammation. Inhibitol is a natural COX-2, 5-LOX, TNF-a, IL-6, and IL-1b inhibitor that helps modulate the production of cytokines.

-------------

Does InflammaSaver’s Inhibitol help control other inflammatory systems?

Inhibitol helps inhibit the release of cyclooxygenase and lipoxygenase and suppress collagenase and phospholipase enzymes, including the iNOX enzyme responsible for initiating the inflammatory process. Inhibitol also hinders the production of thromboxane and leukotriene, powerful triggers of pain and inflammation.

-------------

How does InflammaSaver help reduce pain and inflammation?

InflammaSaver’s proprietary formula of powerful nutraceutical ingredients—including 82 naturally occurring anti-inflammatory phyto-nutrients—enhances the body's ability to control pain and inflammation and restore blood supply to inflamed tissues. Recent studies conducted in France and Germany that compared InflammaSaver to commonly prescribed drugs such as phenylbutazone and cortisone, found that InflammaSaver controlled inflammation and pain without the side effects of the prescription drugs.

-------------

How do the natural ingredients in InflammaSaver work?

InflammaSaver contains salicin and sallcortin, phyto-nutirents that convert in the liver to salisylic acid, the active ingredient in aspirin, but unlike aspirin, these phyto-nutrients also contain natural buffers. InflammaSaver contains sesquiterpene, saponings, alkaloids, terpenoids, and polysaccharides that enhance the body's ability to inhibit prostaglandins and histamines released during the inflammation process. InflammaSaver also has natural antispasmodic properties, and promotes nitric oxide production, peripheral blood flow to the inflamed tissue, and deep-tissue oxygenation. In addition, InflammaSaver has been scientifically demonstrated to boost the immune system and increase resistance to bacterial and viral infection.

-------------

What ailments and injuries may InflammaSaver help alleviate?

InflammaSaver is a natural anti-inflammatory, pain reliever, and immune system booster that may be effective in easing a number of painful conditions. InflammaSaver may enhance the body’s ability to reduce:

Aches and pains

Asthma, respiratory conditions

Atherosclerosis, cardiovascular disease

Bruising

COPD

Breeding problems

Cushing’s syndrome

Dermatitis

DSLD suspensory ligament desimitis

Eczema

Gout

Inflammation

Laminitis

Muscle tie-up

Navicular syndrome

OCD

Osteoarthritis

Osteochondrosis

Osteoporosis

Performance injuries

Psoriasis

Rheumatoid arthritis

Sprains

Stiffness

Swelling

Tendonitis and bursitis

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InflammaSaver helps promote:

Blood flow and oxygen to inflamed and ailing tissue

Immune system health

Post -surgical healing

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Powder Supplement.

Administration

Administer 1 - 2 scoops twice daily.

Ingredients

Inhibitol Proprietary Formula: 50% Salicin Complex (Purpura salix, Fillipendula ulmaria and Gaultheria procumbens), 65% Boswellic Acid Extract (Rhizome), 45% Poliphenols (Camelia sinensis), 50% Resveratrol (Polygonum cuspidatum), 6% Berberine (Barberry and Chinese goldthread), Alkaloid Complex Extract (Uncaria Tomentosa), Origanum vulgare extract, 2% Ursalic acid (Ocimun basilicum), 95% Procyanidins (Vitis vinifera), 23% Phenolics (Rosmarinus ocinalis), Gamma-Tocopherol (Elais gueneensis), Gamma-Tocotrienol (Elaeis gueneensis) and Superoxide Dismutase

Active Ingredient: Inhibitol™

Unfortunately, too few equine practitioners understand that inflammation, pain, and tissue damage are caused by multiple pathological factors, and that chronic inflammation may ultimately lead to even more serous health problems for your horse. The main reason for the high malfunction rate of over-the-counter and prescription analgesic and anti-inflammatory drugs is that they work by targeting only one of the body’s systems. Now Rossana Figuerola, Ph. D., has discovered that the successful management of inflammation and pain and the cascade of dysfunctional symptoms they cause requires that all the known degenerative pathways be restored to proper functioning.

The most dangerous inflammatory-inducing factors are cyclooxygenase-2 (COX-2), 5-lipooxygenase (5-LOX), tumor necrosis factor alpha (TNF-A), and interleukin-1 beta (IL-1b). Figuerola Laboratories has developed InflammaSaver and its active ingredient, Inhibitol to attack the several causes of pain and inflammation with an innovative, multifaceted, natural approach that targets present pain and reduces the chronic inflammation that may cause future disease and disability.

The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Chronic pain is discomfort that lasts longer than six months. Pain intensity may be influenced by the nature of the bodily injury or condition, as well as by environmental and psychological factors.

Inflammation is the body’s natural response to injury. It is characterized by redness, swelling, increased temperature, and pain. When your horse’s soft tissues become inflamed, he may experience any or all of these symptoms. Any organ or tissue of the body can become inflamed, either internally or externally. Inflammation can originate from bacterial or viral infection, physical trauma, or a bodily disorder such as arthritis. External inflammation is usually the result of injury.

Inflammation is currently treated by painkillers and anti-inflammatory medications. While it is true that restoration of normal movement is the key to restoring healthy, pain-free bodily functions, these medications should only be used for the short term, to encourage movement. Although your horse may respond quickly to anti-inflammatories, these drugs often mask pain, while the underlying cause of inflammation remains untreated. In most cases, anti-inflammatories act simply as painkillers, and should only be used in conjunction with regular and appropriate exercise.

Inflammation is usually treated with corticosteroids, phenylbutazone (bute), and non-steroidal anti-inflammatory drugs (NSAIDs). These drugs work by blocking the production of prostaglandins (hormone-like chemicals in the body) that cause pain, inflammation, and cramping. However, prostaglandins also have many essential physiological functions, including regulation of blood pressure, kidney function, and gastric acidity.

Scientists have found that continuous high doses of drugs that inhibit prostaglandin synthesis increase the risk of cumulative toxicity. Some anti-inflammatory drugs, in particular phenylbutazone, can produce serious side effects, such as stroke, heart attack, gastric irritation, stomach ulcerations, bleeding, altered metabolism, and a weakened immune system. Bute has also been shown to cause further deterioration to connective tissues and has been implicated in loss of appetite, changes in blood chemistry, bone marrow depression, kidney damage, etc.

Inflammation and pain are caused by a multi-faceted process, yet most drugs prescribed to lessen inflammation and pain function by using only one of the body’s numerous mechanisms. For instance, COX-2 inhibitor drugs suppress the enzyme cyclooxygenase-2 (COX-2), but do not block the other inflammatory enzyme 5-lipooxygenase (5-LOX).

While a COX-2 inhibitor may provide temporary relief, underlying cartilage damage can continue as inflammatory agents generated by 5-LOX continue to destroy joint cartilage. In addition, destructive cytokines such as tumor necrosis factor alpha (TNF-a) and interleukin-1 beta (IL-1b) cause inflammation and are directly involved in cartilage and bone destruction and organ deterioration. Even if veterinarians prescribe drugs to inhibit COX-2, 5-LOX, TNF-a and IL-1b, other destructive enzymes such as collagenase and phospholipase can continue to trigger the inflammatory process.

Again, most of these drugs use only one of the body’s systems to control inflammation by inhibiting COX-2 or suppressing TNF-a or lowering IL-1b. In addition, cartilage degeneration, which causes arthritis pain, originates from a variety of different factors, so FDA-approved drugs usually provide only partial pain relief. Finally, some of these drugs are also associated with mild to lethal side effects, because they inhibit good enzymes that are essential for the body’s healthy functioning: COX-2 inhibitors like Meloxicam, Carprofen, and Eetodolac have been implicated in serious side effects associated with irreversible COX-1 inhibition.

Many equine degenerative diseases originate with inflammation. Normally, inflammation is a positive process. When your horse experiences a cut, for example, that turns red and swells, his immune system is responding naturally, sending white blood cells and other hormone-like substances to help start the healing process. But not every kind of inflammation is so easy to see, and it's the invisible inflammation that can take place throughout the body that is attracting the increasing scrutiny of scientists and equine practitioners.

Systemic inflammation appears to be an underlying cause of many age-related diseases. As horses grow older, systemic inflammation can inflict devastating degenerative effects throughout the body. The dangers of systemic inflammation have often been overlooked by veterinarians, yet persuasive scientific evidence suggests that correcting a chronic inflammatory disorder can prevent and even reverse infirmities associated with aging. Following specific prevention protocols can significantly reduce inflammatory cycles that damage the body and prevent its healthy, long-term maintenance.

Equine practitioners have begun to believe that chronic inflammation may play a part in triggering a number of serious equine diseases and conditions, including:

• Allergies (inflammatory cytokines induce autoimmune reactions)
• Anemia (inflammatory cytokines attack erythropoietin production)
• Aortic valve stenosis
• Arthritis (inflammatory cytokines destroy joint cartilage and synovial fluid)
• Cancer (chronic inflammation causes many cancers)
• Congestive heart failure (chronic inflammation contributes to heart muscle wasting)
• Dermatitis (inflammatory cytokines induce dermatitis)
• Diabetes (inflammatory cytokines lead to damage of the eyes, kidneys, peripheral circulation, immune system, brain and neurological systems, and cardiovascular system)
• Epiphysitis (damage to the growth plates of the bones, occurring most frequently in younger animals)
• Fibrosis (inflammatory cytokines attack traumatized tissue)
• Heart attack (chronic inflammation contributes to coronary atherosclerosis)
• Hypercholesterolemia (excess cholesterol—chronic inflammation leads to oxidation of cholesterol and deposits in blood vessels)
• Kidney failure (inflammatory cytokines restrict circulation and damage nephrons)
• Muscle tension/spasms
• Obesity (chronic inflammation leads to the development of excess fat which serves as endocrine organ to release inflammatory cytokines)
• Osteochondrosis (caused by a defect in the cartilage overlying the head of one of the long bones)
• Pancreatitis (inflammatory cytokines induce pancreatic cell injury)
• Spondylosis (formation of bone spurs in the vertebrae, usually affecting older animals)
• Stroke (chronic inflammation promotes the occurrence of thromboembolic events)
• Surgical complications (inflammatory cytokines prevent healing)
• Tendonitis

As your horse grows older, there is an increased production of numerous pro-inflammatory chemicals such as cytokines, prostaglandin (G2), C-reactive protein, and thromboxane (A2). These body chemicals lead to the progression of many degenerative diseases, including arthritis, cardiovascular diseases, obesity, and diabetes, among others. Age-related rheumatoid arthritis is a classic autoimmune disorder in which excess levels of cytokines such as tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), interleukin 1-alpha (IL-1a), INF-gamma, and/or interleukin-8 (IL-8) are known to cause or contribute to inflammation.

Cytokines are proteins that serve as signaling chemicals and are secreted by various types of immune cells. The main role of cytokines is to control the direction, amplitude, and duration of the inflammatory response. There are two main groups of cytokines: pro-inflammatory and anti-inflammatory. Pro-inflammatory cytokines are primarily produced by activated immune cells and are involved in the amplification of inflammatory reactions. When a cytokine blood profile is conducted on horses in a weakened condition, an excess level of one or more of the inflammatory cytokines, e.g., TNF-a, IL-6, IL-1b, or IL-8, is usually found.

The active ingredient in InflammaSaver is 100% pure Inhibitol, a proprietary low-molecular-weight formula scientifically designed to help diminish pain and Inflammation. Inhibitol is a natural COX-2, 5-LOX, TNF-a, IL-6, and IL-1b inhibitor that helps modulate the production of cytokines.

Inhibitol helps inhibit the release of cyclooxygenase and lipoxygenase and suppress collagenase and phospholipase enzymes, including the iNOX enzyme responsible for initiating the inflammatory process. Inhibitol also hinders the production of thromboxane and leukotriene, powerful triggers of pain and inflammation.

InflammaSaver’s proprietary formula of powerful nutraceutical ingredients—including 82 naturally occurring anti-inflammatory phyto-nutrients—enhances the body's ability to control pain and inflammation and restore blood supply to inflamed tissues. Recent studies conducted in France and Germany that compared InflammaSaver to commonly prescribed drugs such as phenylbutazone and cortisone, found that InflammaSaver controlled inflammation and pain without the side effects of the prescription drugs.

InflammaSaver contains salicin and sallcortin, phyto-nutirents that convert in the liver to salisylic acid, the active ingredient in aspirin, but unlike aspirin, these phyto-nutrients also contain natural buffers. InflammaSaver contains sesquiterpene, saponings, alkaloids, terpenoids, and polysaccharides that enhance the body's ability to inhibit prostaglandins and histamines released during the inflammation process. InflammaSaver also has natural antispasmodic properties, and promotes nitric oxide production, peripheral blood flow to the inflamed tissue, and deep-tissue oxygenation. In addition, InflammaSaver has been scientifically demonstrated to boost the immune system and increase resistance to bacterial and viral infection.

InflammaSaver is a natural anti-inflammatory, pain reliever, and immune system booster that may be effective in easing a number of painful conditions. InflammaSaver may enhance the body’s ability to reduce:

• Aches and pains
• Asthma, respiratory conditions
• Atherosclerosis, cardiovascular disease
• Bruising
• COPD
• Breeding problems
• Cushing’s syndrome
• Dermatitis
• DSLD suspensory ligament desimitis
• Eczema
• Gout
• Inflammation
• Laminitis
• Muscle tie-up
• Navicular syndrome
• OCD
• Osteoarthritis
• Osteochondrosis
• Osteoporosis
• Performance injuries
• Psoriasis
• Rheumatoid arthritis
• Sprains
• Stiffness
• Swelling
• Tendonitis and bursitis

• Blood flow and oxygen to inflamed and ailing tissue
• Immune system health
• Post -surgical healing

Administer 1 - 2 scoops twice daily.

Inhibitol Proprietary Formula: 50% Salicin Complex (Purpura salix, Fillipendula ulmaria and Gaultheria procumbens), 65% Boswellic Acid Extract (Rhizome), 45% Poliphenols (Camelia sinensis), 50% Resveratrol (Polygonum cuspidatum), 6% Berberine (Barberry and Chinese goldthread), Alkaloid Complex Extract (Uncaria Tomentosa), Origanum vulgare extract, 2% Ursalic acid (Ocimun basilicum), 95% Procyanidins (Vitis vinifera), 23% Phenolics (Rosmarinus ocinalis), Gamma-Tocopherol (Elais gueneensis), Gamma-Tocotrienol (Elaeis gueneensis) and Superoxide Dismutase.

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.